黃勝賢、陳汶吉¹、蔡輔仁²、張進寶

彰化基督教醫院 外科部 泌尿科；¹中國醫藥大學附設醫院 泌尿部，²基因醫學部

Sheng-Hsien Huang, Wen-Chi Chen^1,2, Fuu-Jen Tsai², Chang-Pao Chang

Divisions of Urology, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan; Department of Urology¹ and Medical Genetics², China Medical University Hospital, Taichung, Taiwan

 

Purpose: We investigate the potential association of the transporter associated with antigen processing (TAP1 and TAP2) gene polymorphism with calcium oxalate urolithiasis in Taiwanese.

Materials and Methods: A total 208 calcium oxalate urolithiasis patients and 105 healthy control subjects were enrolled. We analyzed the single nucleotide polymorphisms of TAP1 and TAP2 gene using the polymerase chain reaction (PCR)-based restriction analysis.

Results: There was significant difference in the distribution of the TAP1 gene codon 333 polymorphism frequency between the urolithiasis patients and healthy control subjects (p<0.05). The odds ratio for the risk of the 「A」 allele in calcium oxalate urolithiasis patients was 1.44 (95% CI 1.02 to 2.04). No statically significant difference of TAP2 gene polymorphism frequency was found between the calcium oxalate urolithiasis patients and controls.

Conclusions: TAP1 gene codon 333 polymorphism was associated with the calcium oxalate urolithiasis in Taiwanese. The 「A」 allele had a higher incidence of calcium oxalate urolithiasis. There was lack of association of TAP2 gene polymorphism between calcium oxalate urolithiasis and healthy subjects in Taiwan.

 

論文分類： 3結石	文章屬性：□臨床研究 ■基礎研究 □病例報告
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